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百日咳毒素Pertussis toxin P2980名称 品牌 规格 原始型号 价格Sigma 百日咳毒素Pertussis toxin P2980 EAE模型 多发性硬化模型EAESigma 百日咳毒素Pertussis toxin P2980Pertussis toxin from Bordetella pertussis Sigma 50UG P2980Pertussis toxin from Bordetella pertussis Sigma 0.2MG P2980Pertussis toxin from Bordetella pertussisbuffered aqueous glycerol solutionSynonym: Histamine-sensitizing factor, IAP, Islet Activating Protein, PertussigenCAS Number: 70323-44-3MDL number: MFCD00131841百日咳毒素Pertussis toxinDescriptionPhysical form Aseptically filled solution in 50% glycerol, containing 50 mM TRIS, 10 mM glycine, 0.5 M NaCl, pH 7.5Application The toxin is released from B. pertussis in an inactive form. When the pertussis toxin B oligomer binds to the cell membrane, the S1 subunit of its A protomer becomes activated, perhaps through the action of glutathione and ATP. A protocol for activating pertussis toxin in vitro is given by Kaslow, et al.百日咳毒素Pertussis toxin Biochem/physiol Actions Pertussis toxin catalyzes the ADP-ribosylation of the α subunits of the heterotrimeric guanine nucleotide regulatory proteins Gi, Go, and Gt. This prevents the G protein heterotrimers from interacting with receptors, thus blocking their coupling and activation. Since the Gα subunits remain in their GDP-bound, inactive state, they are unable to inactivate adenylyl cyclase or open K+ channels.性质sterility aseptically packagedform buffered aqueous glycerol solutionstorage temp. −20°C百日咳毒素 Pertussis toxin from Bordetella pertussisProduct Name Pertussis toxin from Bordetella pertussis,buffered aqueous glycerol solutionProduct Number P2980Product Brand SIGMACAS Number 70323-44-3Storage Temp −20°CTEST SPECIFICATIONPurity PassMigrates as five distinct bands when run onPolyacrylamide SDS-Urea gels.Miscellaneous Assay ≤0.33CHO Cell Assay Lowest concentration of toxin atwhich a positive response （clustered growthpattern） is obtained isConcentration 0.2 mg/mlProtein by Bradford授权一级代理，询价请加微信：jinshanbio